Dehydronorketamine (DHNK), or 5,6-dehydronorketamine, is a minor metabolite of ketamine which is formed by dehydrogenation of its metabolite norketamine. Though originally considered to be inactive, DHNK has been found to act as a potent and selective negative allosteric modulator of the α7-nicotinic acetylcholine receptor (IC50 = 55 nM). For this reason, similarly to hydroxynorketamine (HNK), it has been hypothesized that DHNK may have the capacity to produce rapid antidepressant effects. However, unlike ketamine, norketamine, and HNK, DHNK has been found to be inactive in the forced swim test (FST) in mice at doses up to 50 mg/kg. DHNK is inactive at the α3β4-nicotinic acetylcholine receptor (IC50 > 100 μM) and is only very weakly active at the NMDA receptor (Ki = 38.95 μM for (S)-(+)-DHNK). It can be detected 7–10 days after a modest dose of ketamine, and because of this, is useful in drug detection assays.
"}{"fact":"The life expectancy of cats has nearly doubled over the last fifty years.","length":73}
{"fact":"The life expectancy of cats has nearly doubled over the last fifty years.","length":73}
{"fact":"The Ancient Egyptian word for cat was mau, which means \"to see\".","length":64}
["Chillwave palo santo austin selfies post-ironic tonx, sustainable try-hard hella pinterest praxis shoreditch meditation narwhal. Bruh big mood DSA, bespoke shoreditch blog scenester gluten-free yuccie keytar cold-pressed next level hell of literally solarpunk. Kombucha pickled small batch, la croix flexitarian fanny pack pork belly marfa mustache cloud bread mukbang gastropub stumptown. Bicycle rights enamel pin gatekeep, biodiesel before they sold out cupping crucifix kogi. Banjo echo park raw denim slow-carb messenger bag cold-pressed.","You probably haven't heard of them intelligentsia tattooed, pug selvage truffaut small batch air plant yes plz cray. Poke lumbersexual chicharrones photo booth la croix, jawn pabst deep v intelligentsia. Chambray bruh af adaptogen sus. Coloring book succulents readymade wolf. Literally sartorial pork belly schlitz unicorn stumptown craft beer.","8-bit mixtape lumbersexual, vaporware wayfarers sartorial pork belly ugh iPhone banh mi. Helvetica echo park tousled sustainable, hexagon street art tumblr messenger bag humblebrag coloring book. IPhone photo booth chia venmo post-ironic drinking vinegar same cronut raw denim cardigan neutra trust fund etsy. Neutra organic solarpunk, poutine narwhal semiotics kickstarter schlitz trust fund echo park tote bag glossier big mood. Succulents leggings meh tofu craft beer vexillologist. Stumptown gochujang aesthetic gastropub vape kickstarter intelligentsia fingerstache.","Bodega boys sus jawn blue bottle aesthetic tonx ethical bruh chartreuse food truck raclette four dollar toast tumeric hashtag. Sus banh mi yes plz tumeric gatekeep XOXO. Cronut ascot gochujang, drinking vinegar taiyaki tousled venmo. Four dollar toast twee affogato skateboard gorpcore. Lumbersexual microdosing poutine letterpress disrupt actually mustache offal freegan kickstarter hell of.","Messenger bag echo park small batch DSA, tacos marfa bitters fanny pack four loko palo santo celiac forage tofu. Slow-carb lumbersexual fam chicharrones. Organic etsy sartorial yuccie flexitarian. Quinoa portland tote bag pok pok photo booth bespoke. Vexillologist forage bitters franzen. Hot chicken prism man braid, grailed cronut squid pitchfork semiotics taiyaki church-key shoreditch."]
{"slip": { "id": 178, "advice": "It always seems impossible, until it's done."}}
{"type":"standard","title":"Pickett Cotton Mills","displaytitle":"Pickett Cotton Mills","namespace":{"id":0,"text":""},"wikibase_item":"Q21188736","titles":{"canonical":"Pickett_Cotton_Mills","normalized":"Pickett Cotton Mills","display":"Pickett Cotton Mills"},"pageid":47806403,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/f/f4/Pickett_Cotton_Mills.jpg/330px-Pickett_Cotton_Mills.jpg","width":320,"height":213},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/f/f4/Pickett_Cotton_Mills.jpg","width":6016,"height":4000},"lang":"en","dir":"ltr","revision":"1281059292","tid":"db6fd446-0396-11f0-8c60-e8a52071aa71","timestamp":"2025-03-18T01:18:11Z","description":"Historic building in North Carolina, US","description_source":"local","coordinates":{"lat":35.94277778,"lon":-80.01666667},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Pickett_Cotton_Mills","revisions":"https://en.wikipedia.org/wiki/Pickett_Cotton_Mills?action=history","edit":"https://en.wikipedia.org/wiki/Pickett_Cotton_Mills?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Pickett_Cotton_Mills"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Pickett_Cotton_Mills","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Pickett_Cotton_Mills","edit":"https://en.m.wikipedia.org/wiki/Pickett_Cotton_Mills?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Pickett_Cotton_Mills"}},"extract":"The Pickett Cotton Mills is a historic industrial property at 1200 Redding Drive in southwestern High Point, North Carolina. The mill complex includes the original 1911 two-story brick-and-concrete mill building, a storage warehouse, office building, and sprinkler house. The Pickett Cotton Mill Company was founded in 1910, and was the first successful textile operation in the city. The mill was closed in 1985 due to stiff foreign competition. The main mill is an exemplary instance of sturdy, high-quality construction of the period, and the office building, which is also typical of the period, is one of the few to survive.","extract_html":"
The Pickett Cotton Mills is a historic industrial property at 1200 Redding Drive in southwestern High Point, North Carolina. The mill complex includes the original 1911 two-story brick-and-concrete mill building, a storage warehouse, office building, and sprinkler house. The Pickett Cotton Mill Company was founded in 1910, and was the first successful textile operation in the city. The mill was closed in 1985 due to stiff foreign competition. The main mill is an exemplary instance of sturdy, high-quality construction of the period, and the office building, which is also typical of the period, is one of the few to surviv